Whether or not a microbe is successful at establishing an infection depends both on the microbe and the host. Scientists from Duke found that a single DNA change can allow Salmonella typhi, the bacteria that causes typhoid fever, to invade cells. That single genetic variation increased the amount of cholesterol on cell membranes that Salmonella and other bacteria use as a docking station to attach to a cell to invade it. They also found that common cholesterol-lowering drugs protected zebrafish...
Bacteria, viruses and other germs sometimes set off the immune system to overreact, producing a severe condition called sepsis. Sepsis is so dangerous that it is the leading cause of death of children across the world, killing a million kids every year, mostly in developing countries. Probiotic bacteria might be able to prevent sepsis and infections, but no large research studies have been done to find out whether that actually works. Until now.
How can a drug used to treat cancer be effective against viruses, too? The answer lies in the drug's shared target — specifically, cellular components that control the activity of genes. A new research study showed that one such type of drug, histone methyltransferase inhibitors used in cancer clinical trials, has activity against herpes simplex virus, too.
Scientists know that bacteria create their own energy, get nutrients to run their cellular processes, and multiply. But, bacteria haven't been shown to respond to external mechanical stimulation or signals in a way that's similar to how our bodies respond to touch, until now.
For about a million Americans each year, a joint replacement brings relief from pain and restored mobility. But, 5–10% of those people have to endure another surgery within seven years, and most of those are due to an infection in their new joint. If doctors could treat infections more effectively, patients could avoid a second surgery, more pain, and another rehabilitation.
Infections with group A streptococcus, like Streptococcus pyogenes, claim over a half million lives a year globally, with about 163,000 due to invasive strep infections, like flesh-eating necrotizing fasciitis and streptococcal toxic shock syndrome.
More than one in ten people in the US have type 2 diabetes — that's over 29 million people. It's characterized by excessive sugar (glucose) in the blood due to the development of resistance to insulin, the hormone that normally metabolizes glucose.
Once we recover from the respiratory infection pneumonia, our lungs are better equipped to deal with the next infection — thanks to some special cells that take up residence there.
Cancer cells do a pretty good job of flying under the radar of our immune system. They don't raise the alarm bells signaling they are a foreign invader the way viruses do. That might be something scientists can change, though.
Antibiotics are one of our main weapons against infections. The problem is that many bacteria are becoming resistant to most of the antibiotics we use to treat them, and those 'superbugs' have created an urgent threat to our global health. A research group found a new way to hit a well known bacterial target and have developed a drug to hit it.
Young girls, especially those who live in areas where HIV is epidemic, like sub-Saharan Africa, are particularly vulnerable to becoming infected with HIV. A vaginal ring containing the antiviral agent dapivirine has been shown to decrease the chance of developing HIV-1 in adult women over 21 and now in the first step for use in adolescents, the ring has been shown to be safe and well-tolerated in that younger age group.
Growing evidence suggests that neurodegenerative diseases like Parkinson's may develop in part due to environmental factors, including infections that can cause inflammation in the nervous system. New research from investigators from Jude Children's Research Hospital and Thomas Jefferson University has strengthened that connection.
For a company more associated with debugging computer programs, Google's parent company, Alphabet, is making a name for itself by taking on the real thing — mosquitoes.
Flu vaccines can help prevent us from getting or suffering the most severe effects of the flu. But, each vaccine only protects us from three different strains of the flu. If we don't have a vaccine against all types of flu, it leaves us open for an epidemic with a flu virus we didn't expect.
Malaria is a massive worldwide health problem. The Centers for Disease Control and Prevention estimate that 212 million cases of malaria occurred worldwide in 2015 and 429,000 of the infected people died.
About a third of the methane released into the environment comes from the production and transport of natural gas. The gas leaks as it moves along the transport chain from gas wellheads to market.
With a death rate of one in five, sepsis is a fast-moving medical nightmare. New testing methods might improve your odds of survival if this infection ever hits you.
Cytochrome P450 (P450s) are proteins found in nearly all living organisms, which play roles that range from producing essential compounds and hormones to metabolizing drugs and toxins. We use some of the compounds synthesized by P450 in plants as medical treatments, but the slow growth and limited supply of these plants have put the drugs' availability in jeopardy and jacked up prices.
Heart disease is the leading cause of death of men and women in the US. Over half a million Americans die from it annually. Atherosclerosis — a build up of plaque in the arteries — is a common feature of heart disease and can be caused by smoking, fats and cholesterol in the blood, diabetes, and high blood pressure.
Colorectal cancer — cancer of the colon or rectum — is the third most commonly diagnosed cancer in the US. To reduce the chances of a diagnosis we are all urged to stop smoking, keep our weight down, decrease our intake of alcohol and red meat, keep active, and get screened for colon cancer. But, new research has found something that participates in the development of colorectal cancer that might not be as easy to control: A strep bacteria that promotes tumor growth.
As our cells age, they eventually mature and die. As they die, they alert nearby cells to grow and multiply to replace them. Using a special imaging process that combines video and microscopy, scientists have observed the cellular communication between dying and neighboring cells for the first time, and think they may be able to use their new-found information against cancer cells, whose damaged genomes let them escape the normal dying process.
Even though HIV rates declined 18% between 2008 and 2014, 1.1 million people in the US are living with the infection. Part of that is because HIV is treatable, but not curable.
Type 1 diabetes is an attack on the body by the immune system — the body produces antibodies that attack insulin-secreting cells in the pancreas. Doctors often diagnose this type of diabetes in childhood and early adulthood. The trigger that causes the body to attack itself has been elusive; but many research studies have suggested viruses could be the root. The latest links that viruses that live in our intestines may yield clues as to which children might develop type 1 diabetes.
Natural remedies used through the ages abound, especially in Asian medicine. The willow-leaved justicia plant, found throughout Southeast Asia, has traditionally been used to treat arthritis, but scientists have just discovered it contains an anti-HIVcompound more potent than AZT. AZT was the first drug approved to treat HIV, and is still used in HIV combination therapy today.
A promising new antibiotic has been discovered in, of all things, another bacteria. Burkholderia bacteria live in diverse habitats, including soil, plants, and humans where they thrive by knocking out other microbes that compete with them for resources or threaten their existence. Scientists have discovered they accomplish this by producing a very effective antibiotic.
New research reveals how E. coli bacteria construct elaborate and effective tunnels to pump unwanted molecules like antibiotics and other toxins out of cells. The discovery could help us better understand how antibiotic resistance occurs and give us a leg-up to beat them at their own game.
A new medical development is going to change the way many of us look at getting the flu vaccine. A painless flu vaccine skin patch is making needles and vials a thing of the past. Researchers from the Georgia Institute of Technology and Emory University have shown that a flu vaccine can be administered safely and comfortably with this new patch, which delivers the vaccine through a matrix of tiny dissolving microneedles.
Look no further than Flint, Michigan, to discover the serious consequences of contaminated drinking water. Around the world, water polluted by pathogens and toxins sickens people or cuts them off from safe drinking water. Looking for a solution, researchers created tiny, swimming robots that pack a powerful punch against waterborne pathogens.
Coronaviruses are common viruses, and most of us catch one at some point — they cause about 30% of all common colds. A new accidental discovery could help fight these viruses, even the deadlier, emerging ones.
People who have heart disease get shingles more often than others, and the reason has eluded scientists since they first discovered the link. A new study has found a connection, and it lies in a defective white cell with a sweet tooth.
What would it be like to have clothing that killed microbes? Or paper that repelled pathogens? A research team from Rutgers University has developed a prototype out of metalized paper to zap the bad guys without being super expensive. Sound good? Read on.
Some types of bacterial infections are notoriously tough to treat — and it's not all due to antibiotic resistance. The bacteria themselves are rugged and hard to penetrate with drugs.
If the all the fingerlike projections in our gut were flattened out, its surface area would be 100 times bigger than our skin's. It's so large that the actions of just a small part of it can impact our health. A new research study has found that enterochromaffin cells in the intestinal lining alert the nervous system to signs of trouble in the gut — trouble that ranges from bacterial products to inflammatory food molecules.
Respiratory Syncytial Virus (RSV) is the most commonly occurring lower respiratory tract viral infection in young children and usually isn't serious, but in premature infants and babies under six months old, the infection can be severe, and even fatal.
Alzheimer's disease — an irreversible, progressive brain disorder — is the sixth leading cause of death in the US and more than afflicts 5 million Americans. As if those numbers aren't scary enough, the Centers for Disease Control and Prevention expect that number to nearly triple by 2050.
Yogurt is more than an excellent source of protein, calcium, and gut-healthy probiotic bacteria. A protein isolated from probiotic lactobacillus bacteria in yogurt is capable of inhibiting drug-resistant bacteria.
Zika is a threat to unborn babies — the virus can cause neurological damage if it infects a mother during pregnancy. But as with many things, our solutions to the problem aren't always all that much better than the problem itself.
Several recent research studies have pointed to the importance of the microbes that live in our gut to many aspects of our health. A recent finding shows how bacteria that penetrate the mucus lining of the colon could play a significant role in diabetes.
Listeria monocytogenes bacteria don't play fair. Healthy people can usually handle the food-borne infection, but the bacterial infection hits pregnant women, fetuses and cancer patients very hard. Interestingly, a new study found that other bacteria may help prevent Listeria infections in those people.
Most of us have already had an encounter with the Epstein-Barr virus, or EBV, for short. As part of the herpes family, it's one of the most common disease-causing viruses in humans. We get the disease with (or without) some nasty symptoms, then we recover. However, EBV stays in our body after the illness has ended, and it's one of the few viruses known to cause cancer.
Dengue fever is a danger to anyone living or visiting tropical or subtropical regions. It can be hard to detect the infection in its earliest and most treatable phase, especially in children. Luckily, new research highlights better techniques for triaging the disease in infected children with more severe symptoms, potentially saving lives.
Dramatic new research may change the fate of the hundreds of people who wait for a kidney transplant every year. The study hinged on the ability to cure hepatitis C infections, a possibility that became a reality in 2014.
The Centers for Disease Control and Prevention estimated that there were 212 million cases of malaria across the world in 2015, and 429,000 of those people died — mostly children living in Africa. Preventing and treating those infections has been a challenging world priority. That makes a new malaria drug discovery — published in Science Translational Medicine — incredibly important.
The problem with HIV is that it attacks and kills the very cells of the immune system that are supposed to protect us from infections — white blood cells. But a new technique, developed by scientists at The Scripps Research Institute (TSRI) in La Jolla, California, offers a distinct HIV-killing advantage.
Mitochondria are known as the powerhouses of our cells because they generate energy to power them. But they also play a key role in the death of cells when they're damaged, infected, stressed, no longer needed, or at the end of their life.
The evolution of our infection-fighting systems may have something to teach modern scientists. That's what a group from the University of Granada in Spain found when they studied a protein that's been around for over four billion years. Their work, by senior author José Sánchez-Ruiz and colleagues in the Department of Physical Chemistry, was published in the journal Cell Reports.
While at work, you notice your gloves changing color, and you know immediately that you've come in contact with dangerous chemicals. Bandages on a patient signal the presence of unseen, drug-resistant microbes. These are ideas that might have once seemed futuristic but are becoming a reality as researchers move forward with technology to use living bacteria in cloth to detect pathogens, pollutants, and particulates that endanger our lives.
Being infected with HIV means a lifetime of antiviral therapy. We can control the infection with those drugs, but we haven't been able to cure people by ridding the body completely of the virus. But thanks to a new study published in Molecular Therapy by scientists at the Lewis Katz School of Medicine (LKSOM) at Temple University and the University of Pittsburgh, all that may change.
Colorado State University scientists have developed new tech that quickly identifies the presence of Zika virus in mosquito populations — and in human body fluid.
Pertussis, or whooping cough, is a highly contagious disease that can be life-threatening for young children. New research backs a recommendation that all pregnant women receive a pertussis booster with each pregnancy, as it can help their infants fight off the infection.
It's not the bacteria itself that takes lives and limbs during invasive flesh-eating bacteria infections. It's the toxins secreted by the group A Streptococcus bacteria invading the body that causes the most damage.
