Innovation

Whether or not a microbe is successful at establishing an infection depends both on the microbe and the host. Scientists from Duke found that a single DNA change can allow Salmonella typhi, the bacteria that causes typhoid fever, to invade cells. That single genetic variation increased the amount of cholesterol on cell membranes that Salmonella and other bacteria use as a docking station to attach to a cell to invade it. They also found that common cholesterol-lowering drugs protected zebrafish...

Scientists know that bacteria create their own energy, get nutrients to run their cellular processes, and multiply. But, bacteria haven't been shown to respond to external mechanical stimulation or signals in a way that's similar to how our bodies respond to touch, until now.

More than one in ten people in the US have type 2 diabetes — that's over 29 million people. It's characterized by excessive sugar (glucose) in the blood due to the development of resistance to insulin, the hormone that normally metabolizes glucose.

Antibiotics are one of our main weapons against infections. The problem is that many bacteria are becoming resistant to most of the antibiotics we use to treat them, and those 'superbugs' have created an urgent threat to our global health. A research group found a new way to hit a well known bacterial target and have developed a drug to hit it.

Growing evidence suggests that neurodegenerative diseases like Parkinson's may develop in part due to environmental factors, including infections that can cause inflammation in the nervous system. New research from investigators from Jude Children's Research Hospital and Thomas Jefferson University has strengthened that connection.

Malaria is a massive worldwide health problem. The Centers for Disease Control and Prevention estimate that 212 million cases of malaria occurred worldwide in 2015 and 429,000 of the infected people died.

Cytochrome P450 (P450s) are proteins found in nearly all living organisms, which play roles that range from producing essential compounds and hormones to metabolizing drugs and toxins. We use some of the compounds synthesized by P450 in plants as medical treatments, but the slow growth and limited supply of these plants have put the drugs' availability in jeopardy and jacked up prices.

As our cells age, they eventually mature and die. As they die, they alert nearby cells to grow and multiply to replace them. Using a special imaging process that combines video and microscopy, scientists have observed the cellular communication between dying and neighboring cells for the first time, and think they may be able to use their new-found information against cancer cells, whose damaged genomes let them escape the normal dying process.

Natural remedies used through the ages abound, especially in Asian medicine. The willow-leaved justicia plant, found throughout Southeast Asia, has traditionally been used to treat arthritis, but scientists have just discovered it contains an anti-HIVcompound more potent than AZT. AZT was the first drug approved to treat HIV, and is still used in HIV combination therapy today.

A new medical development is going to change the way many of us look at getting the flu vaccine. A painless flu vaccine skin patch is making needles and vials a thing of the past. Researchers from the Georgia Institute of Technology and Emory University have shown that a flu vaccine can be administered safely and comfortably with this new patch, which delivers the vaccine through a matrix of tiny dissolving microneedles.

Bone loss and belly fat may no longer be certain fates of menopause, thanks to new research from an international team of scientists.

Some types of bacterial infections are notoriously tough to treat — and it's not all due to antibiotic resistance. The bacteria themselves are rugged and hard to penetrate with drugs.

Alzheimer's disease — an irreversible, progressive brain disorder — is the sixth leading cause of death in the US and more than afflicts 5 million Americans. As if those numbers aren't scary enough, the Centers for Disease Control and Prevention expect that number to nearly triple by 2050.

Several recent research studies have pointed to the importance of the microbes that live in our gut to many aspects of our health. A recent finding shows how bacteria that penetrate the mucus lining of the colon could play a significant role in diabetes.

Dengue fever is a danger to anyone living or visiting tropical or subtropical regions. It can be hard to detect the infection in its earliest and most treatable phase, especially in children. Luckily, new research highlights better techniques for triaging the disease in infected children with more severe symptoms, potentially saving lives.

The problem with HIV is that it attacks and kills the very cells of the immune system that are supposed to protect us from infections — white blood cells. But a new technique, developed by scientists at The Scripps Research Institute (TSRI) in La Jolla, California, offers a distinct HIV-killing advantage.

The evolution of our infection-fighting systems may have something to teach modern scientists. That's what a group from the University of Granada in Spain found when they studied a protein that's been around for over four billion years. Their work, by senior author José Sánchez-Ruiz and colleagues in the Department of Physical Chemistry, was published in the journal Cell Reports.

Colorado State University scientists have developed new tech that quickly identifies the presence of Zika virus in mosquito populations — and in human body fluid.